Michael Ferracane

Assistant Professor
Chemistry

Michael Ferracane

Areas of Expertise

  • Design and synthesis of cyclic peptide-based modulators of the opioid receptors and histone deacetylases
  • Analysis of cyclic peptide structure via NMR spectroscopy and X-ray crystallography
  • Incorporation of active teaching techniques in the organic chemistry curriculum

Education

Ph.D., Organic Chemistry, University of Virginia, 2014

 

B.S., Chemistry & Biochemistry, University of Arizona, 2008

For the Media

Contact :
Jennifer Dobbs
909.748.8857 

Contact

Chemistry, Hedco Hall
206
P: 909.307.7818
P: 909.748.8370
E: Michael_Ferracane@redlands.edu

Background

I am a computational and synthetic organic chemist by training. In the past, my research has focused on developing novel small molecules and peptides intended to modulate the activity of the sphingosine 1-phosphate and opioid receptors. These receptor families are important targets for the treatment of multiple sclerosis and pain respectively. As a new faculty member at the University of Redlands, I intend to unite and expand upon this research, synthesizing cyclic peptides intended to treat pain, addiction, or cancer. This research will contribute new knowledge to the field while providing students interested in the chemical or health sciences with a meaningful research experience.

My research lies within the field of medicinal chemistry and uses different methods to design, synthesize, and investigate the properties and therapeutic potential of cyclic peptides. Current research is focused on:

  • Design and synthesis of cyclic peptide-based modulators of the opioid receptors and histone deacetylases

  • Analysis of cyclic peptide structure via NMR spectroscopy and X-ray crystallography

  • Incorporation of active teaching techniques in the organic chemistry curriculum

 

 

Degrees held

Ph.D., Organic Chemistry, University of Virginia, 2014

 

B.S., Chemistry & Biochemistry, University of Arizona, 2008

Experience

·       Assistant Professor, Department of Chemistry, University of Redlands

·       Post-Doctoral Associate, Department of Medicinal Chemistry, University of Florida

Courses Offered

  • ·       CHEM 231 Organic Chemistry I Lecture and Lab

    ·       CHEM 232 Organic Chemistry II Lecture and Lab

    ·       CHEM 320 Biochemistry Lecture and Laboratory

Publications

  • Malaker, S.; Ferracane, M.; Depontieu, F.; Zarling, A.; Shabanowitz, J.; Bai, D.; Engelhard, V.; Topalian, S.; Hunt, D. Identification and characterization of complex glycosylated peptides presented by the MHC class II processing pathway in melanoma. Journal of Proteome Research (in press). http://dx.doi.org/10.1021/acs.jproteome.6b00496

     

    Ferracane, M.; Aldrich, J. Opioid ligand binding to opioid receptors: insight and implications for peptide design. Proceedings of the 24th American Peptide Symposium 201524, 22-23. http://dx.doi.org/10.17952/24APS.2015.022

     

    Lefever, M.; Szabo, L.; Anglin, B.; Ferracane, M.; Hogan, J.; Cooney, L.; Polt, R. Glycosylation of α-amino acids by sugar acetate donors with InBr3. Minimally competent Lewis acids. Carbohydrate Research 2012351, 121-125. http://dx.doi.org/10.1016/j.carres.2012.01.008

Awards, Honors, Grants

  • ·       Bert L. Schram Young Investigator Award – 2015

    ·       Outstanding Graduate Teaching Assistant Award – 2014

    ·       Alumni Award for Excellence in Undergraduate Research – 2007

Profesional Affiliations

  • ·       American Chemical Society

    ·       American Peptide Society

    ·       Council on Undergraduate Research